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Diabetes Presentation templates

Here at slidesgo, we would like to help you raise awareness about diabetes, a metabolic disorder related to insulin and the levels of glucose in our blood. with these google slides & powerpoint templates, you can make sure that the audience will pay attention to your speech, as these slides will keep them focused on the screen and your explanations..

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Diabetes infographics.

Information on health issues requires pedagogical resources to make it understandable to others. At Slidesgo we have created this diabetes infographic template so that you can easily and entertainingly report on this disease. It contains numerous icons and illustrations to make the data more visual and easier to remember. With...

World Diabetes Day

Diabetes is a serious illness that affects millions of people all around the world, and making proper treatment, care and information accessible to everyone who needs it is an unresolved issue that needs more awareness. For reasons like these, the United Nations decided to establish November 14th as the World...

Type 2 Diabetes Breakthrough

Type 2 diabetes is a metabolic disorder with a high prevalence in the world. Hundreds of millions of people suffer from it every year. Basically, a person cannot produce enough insulin, which can cause very severe consequences. Are there news on the treatment of type 2 diabetes? Waste no time...

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Diabetes Devices and Technology Breakthrough

This modern and cool template is the perfect way to showcase the amazing breakthroughs in diabetes technologies and devices. With this template, you can easily present the latest developments to help treat and control diabetes. It features modern visuals and graphics that provide insight into the technology, as well as...

Diabetes Breakthrough: Insulin Increase

This is a modern template full of illustrations and resources that gives medical presentations a visual and creative touch. This design focuses on diabetes: a medical issue that affects the lives of millions of people. If you have investigated on this and have come up with a new treatment, these...

Diabetic Mastopathy Clinical Case

Download the Diabetic Mastopathy Clinical Case presentation for PowerPoint or Google Slides. A clinical case is more than just a set of symptoms and a diagnosis. It is a unique story of a patient, their experiences, and their journey towards healing. Each case is an opportunity for healthcare professionals to...

Gestational Diabetes

Gestational diabetes is diabetes that first appears during pregnancy. It usually occurs in the middle of the gestation period and it is necessary to take care of it so that it does not cause problems. For this, information is key, so we have created this beautiful pink template, with creative...

Diabetes Mellitus Breakthrough

Diabetes mellitus refers to a group of diseases that affects the way the body uses blood glucose. Many people in the world suffer from this disease, and we are sure that your breakthrough will give a new perspective to its diagnosis and treatment. Present it with this complete and impressive...

World Diabetes Day Infographics

Slidesgo is aware of how healthcare professionals love to have extra help when sharing information about diseases, treatments or breakthroughs. Today, we're releasing a series of infographic designs for presentations about diabetes, a serious illness that affects millions of people. Check them out! The main color used is blue, a...

Kidney Diseases: Diabetic Nephropathy

Download the Kidney Diseases: Diabetic Nephropathy presentation for PowerPoint or Google Slides. Taking care of yourself and of those around you is key! By learning about various illnesses and how they are spread, people can get a better understanding of them and make informed decisions about eating, exercise, and seeking...

Download the "Gestational Diabetes" presentation for PowerPoint or Google Slides. Taking care of yourself and of those around you is key! By learning about various illnesses and how they are spread, people can get a better understanding of them and make informed decisions about eating, exercise, and seeking medical attention....

Treatment of Hypoglycemia Breakthrough

When the glucose levels in our blood drop below normal, our body can experience symptoms such as shakiness, confusion, sweating, and fatigue. A more correct name for this condition is hypoglycemia, but there's treatment (usually, ingesting sugar and carbohydrates), but perhaps there's more to it. Any new breakthrough in this...

Labor Induction for Gestational Diabetes Breakthrough

Download the Labor Induction for Gestational Diabetes Breakthrough presentation for PowerPoint or Google Slides.Treating diseases involves a lot of prior research and clinical trials. But whenever there’s a new discovery, a revolutionary finding that opens the door to new treatments, vaccines or ways to prevent illnesses, it’s great news. Should...

Type 2 Diabetes Disease

Type 2 diabetes is a chronic condition that affects the way the body processes glucose. With this disease, the patient's body does not produce enough insulin or is resistant to it. Share your research on this important disease using this modern and minimalist template designed in pastel colors, with which...

Diabetes Education Center

Running a medical center specialized on diabetes involves lots of organization and management. What is the admission procedure? How are patients going to be allocated? What fun/free time activities do you offer? That’s an important question to think about, because offering your patients activities to disconnect can improve their mental...

Happy World Diabetes Day!

Celebrate World Diabetes Day in style with our fully editable Google Slides and PowerPoint template. Complete with illuminating light green design and vivid photographs, it provides a perfect platform to give an informative presentation about diabetes, its varied types, and summarize significant research. It also offers a fantastic opportunity to...

Gestational Diabetes Breakthrough

Download the Gestational Diabetes Breakthrough presentation for PowerPoint or Google Slides.Treating diseases involves a lot of prior research and clinical trials. But whenever there’s a new discovery, a revolutionary finding that opens the door to new treatments, vaccines or ways to prevent illnesses, it’s great news. Should there be a...

Diabetes Mellitus Disease

Diabetes mellitus refers to a group of diseases that affects the way the body uses blood glucose. Glucose is vital for health, as it is an important source of energy for the cells that make up muscles and tissues. Understanding a disease thoroughly is the first step to being able...

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Encore Presentation, The National Diabetes Prevention Program — Changing Lifestyles to Prevent Type 2 Diabetes

Originally presented on Tuesday, November 13, 2018 . Encore presentation on Tuesday, March 17, 2020 .

Diabetes is a serious public health problem. About 34 million Americans have diabetes, and more than 88 million American adults have prediabetes. People with prediabetes have blood sugar levels that are higher than normal, but not high enough to be diagnosed with type 2 diabetes. They are at risk for type 2 diabetes, heart attack and stroke, but lifestyle changes, such as losing weight and increasing physical activity, can reduce their risk and may even prevent the onset of type 2 diabetes.

Learn how participating in the CDC-led National Diabetes Prevention Program lifestyle change program can help prevent or delay type 2 diabetes in those at high risk.

Dr. John Iskander & Dr. Ann Albright discuss how participating in the CDC-led National Diabetes Prevention Program can help prevent or delay type 2 diabetes in those at high risk.

The National Diabetes Prevention Program — Changing Lifestyles to Prevent Type 2 Diabetes

Drs. Phoebe Thorpe and Ann Albright discuss the serious public health problem of diabetes and the CDC-led National Diabetes Prevention Program .

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• Presentation Slide Deck [3.9MB, 67 Pages, HTML]
• Could You Have Prediabetes? Take the Risk Test.

CDC Course Code: PHGR10 CPE UAN: JA4008229-0000-20-070-H04-P

For more information, see Grand Rounds Continuing Education.

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Free Diabetes Presentation Templates

Struggling with boring diabetes presentations download free diabetes powerpoint templates and google slides themes that are easy to use and understand. bright colors, creative visuals, and helpful infographics - make your message clear spread awareness about diabetes mellitus, including causes, symptoms, diets, etc. the best choice for doctors.

• Diverse themes: Explore slides dedicated to diabetic ketoacidosis, case studies, diet plans, and even captivating backgrounds for your chosen topic.
• World Diabetes Day: Celebrate this special day with slides that everyone will understand! It will help you raise awareness and make people want to learn more about keeping their sugar in check.
• Let creativity flow: Infographics, multicolor palettes, and a variety of layouts give your presentation a unique and impactful edge.
• Customization: All slides are 100% editable, allowing you to tailor them to your specific needs and add your own touch.
• Multiple formats: Choose from 4:3 or 16:9 aspect ratios, portrait or landscape orientations, and find slides that work seamlessly with any presentation platform.
• Free options to explore: A collection of diabetes PPT presentation free downloads available to let you experience the quality before investing further.
• Doctors, nurses, and teachers: Explain things clearly to patients, friends, and everyone else.
• People who spread the word about diabetes: Teach people how to stay healthy and avoid problems with sugar.
• People living with diabetes: Share your story and help others, or fight for better care with powerful pictures. It will help to share your experiences and make a difference!
• Conferences and workshops: Deliver impactful presentations at medical gatherings, community events, and educational seminars.
• Patient education sessions: Use clear visuals to explain complex topics to patients and families in an accessible and engaging way.
• Awareness campaigns: Create presentations that raise awareness about diabetes , its impact, and steps for prevention and management.
• Online presentations and webinars: Share your knowledge with a wider audience through online platforms using visually compelling slides.

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What types of diabetes presentation templates are available.

We offer a variety of templates for different topics, including awareness campaigns, patient education, research presentations, and more.

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Not at all! Our templates are made for everyone, even if you're just starting. Just put in your content and change the look with a few clicks – it's that easy!

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Yes, you can fully customize the templates with your own content, images, and colors. You can edit them from PowerPoint or Google Slides.

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Diabetes Presentation Template

Customize the Diabetes presentation template for PowerPoint & Google Slides to present your diabetes awareness presentations comprehensively. Diabetes is a chronic disease that alters the normal glucose level of the body and can lead to various complications. The major cause of diabetes is the decreased production of insulin. The prevalence of this disease is more than ever, and it’s crucial to understand the causes and risk factors associated with diabetes. We have specifically designed this interactive PowerPoint template for social workers, healthcare experts, and doctors. So that they can create useful presentations for the audience while accomplishing diabetes awareness campaigns. November is National Diabetes Month, and it is important to educate the public about diabetes.

Our Diabetes presentation template can also be used in executive sessions to present support for diabetes funding, research, and awareness. The title slide contains the diagram of a glucometer connected with a blue diabetes support ribbon. The further slides contain human illustrations with a diagram of the glucometer, pricker, and test strips, which can help the audience understand safe sugar levels and risky conditions. Moreover, in the following slide, a weighing balance shows that the significance of fruits is higher than fast food. Some other slides are:

• Symptoms slide to describe the signs of the poor health condition
• Horizontal timeline slide with editable textboxes to demonstrate the history of diabetes and its futuristic details.
• Data-driven charts slide and column chart slides to mention the relevant data about the prevalence and occurrence of diabetes patients and the increasing number of patients.

This creative diabetes template is compatible with all versions of Microsoft PowerPoint, Google Slides, and Keynote. The users can change the slides’ colors, relevant graphical elements, icons, and theme according to their preferences. So, download this useful PPT template and make amazing presentations in the diabetes month of November. Alternatively, you can download the Diabetes PPT template design with other useful slides that you can use in your presentation on diabetes topics.

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Diabetes. Nhung H. Nguyen. Definition:. “A metabolic disease in which the body’s inability to produce any or enough insulin causes elevated levels of glucose in the blood.”. Types of diabetes:. Type 1 Type 2 Gestational diabetes Prediabetes. Type 1 diabetes:.

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Presentation Transcript

Diabetes Nhung H. Nguyen

Definition: • “A metabolic disease in which the body’s inability to produce any or enough insulin causes elevated levels of glucose in the blood.”

Types of diabetes: • Type 1 • Type 2 • Gestational diabetes • Prediabetes

Type 1 diabetes: • Also known as juvenile diabetes • Usually diagnosed in children and young adults • When body’s own immune system destroys the insulin producing cells of the pancreas – beta cells – which produce insulin • Only 5% of people have this disease • Body does not produce insulin • Is not preventable • No primary intervention • Causes? • Predisposition to diabetes – genetics - and something (i.e. weather, virus ... etc ) in environment triggers the disease

Symptoms of Diabetes:

Type 2 diabetes: • Most common form of diabetes – about 90% of cases • Used to be called adult onset, non insulin dependent diabetes • Body produces insulin, but does not use it properly • glucose doesn’t move into cells, they pile up in the bloodstream • sx’s when they do occur are often ignored because they may not seem serious

Risk factors: • Genetics • Family pmHx • Polycystic ovary syndrome • Irregular menses • Race • African Americans, Hispanics and Asians > whites • Age • After age 45, but increases in younger adults and children • Environmental factors • Inactivity • Weight gain

Gestational diabetes mellitus (GDM): • Having diabetes during pregnancy • Family Hx of diabetes, overweight prior to pregnancy? • Having gestational diabetes puts you at risk for diabetes type 2 • Giving birth to a baby >9 lbs also puts you at risk for type 2 • 18 out of every 100 pregnant females will develop GDM

Complications for uncontrolled diabetes:

How to monitor your diabetes:

Preventions: • Type 1: • Not preventable, as of right now. • Studies on ways to possible prevent further destruction of the beta cells • Maintain and control sugar levels, insulin injection • Healthy life style – exercise and diet • Islet transplantation?

Preventions: • Type 2: • Primary: maintain a healthy lifestyle • Secondary: check HgA1c, adjust diet • HgA1c – blood sugar avg over span of 3 months • Measures what % of your Hg is coated with sugar • Nl = 4 % - 5.6%, pre diabetes = 5.7% -6.4% and diabetes = 6.5% + • Tertiary: exercise and eat well • Foot exam?

Preventions: • Gestational diabetes: • Physical activity • Researchers found being physically active before and after their pregnancy reduced their risk of GDM by about 70% or more • Diet • A study showed that each 10 gram increase in fiber a day reduced their risk of GDM by 26%

U.S. Prevalence:

Diabetes and Obesity:

Cost of Diabetes (US):

Global prevalence: http://www.idf.org/atlasmap/atlasmap

Global prevalence:

Prediabetes:

Prediabetes: • Diabetes prevention program • Lifestyle intervention group vs medicated group with Metformin vs placebo group • 3,243 participants were overweight and had prediabetes • Lifestyle intervention reduced diabetes by 58% • Metformin reduced diabetes by 31% • Effective in both sexes ages 25-44 yoa and BMI of 30 + Summary: Type 2 diabetes can be prevented/delayed with activity and diet.

Twin study:

The Future:

Websites: • http://www.idf.org/about-diabetes • global • http://www.diabeteseducator.org/ • http://www.cdc.gov/diabetes/home/ • http://www.diabetes.org/ • U.S.

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• Published: 20 July 2024

Risk of chronic kidney disease in patients with a hyperglycemic crisis as the initial presentation of type 2 diabetes

• Chun-Ta Huang 1 , 2 ,
• Chih-Hsin Muo 3 ,
• Fung-Chang Sung   ORCID: orcid.org/0000-0003-3542-8552 3 , 4 , 5 &
• Pei-Chun Chen 6  

Scientific Reports volume  14 , Article number:  16746 ( 2024 ) Cite this article

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Metrics details

• Chronic kidney disease
• Outcomes research
• Type 2 diabetes

Limited data exist on long-term renal outcomes in patients with hyperglycemic crisis (HC) as initial type 2 diabetes presentation. We evaluated the risk of chronic kidney disease (CKD) development in those with concurrent HC at diagnosis. Utilizing Taiwan’s insurance claims from adults newly diagnosed with type 2 diabetes during 2006–2015, we created HC and matched non-HC cohorts. We assessed incident CKD/diabetic kidney disease (DKD) by 2018’s end, calculating the hazard ratio (HR) with the Cox model . Each cohort comprised 13,242 patients. The combined CKD and DKD incidence was two-fold higher in the HC cohort than in the non-HC cohort (56.47 versus 28.49 per 1000 person-years) with an adjusted HR (aHR) of 2.00 (95% confidence interval [CI] 1.91–2.10]). Risk increased from diabetic ketoacidosis (DKA) (aHR:1.69 [95% CI 1.59–1.79]) to hyperglycemic hyperosmolar state (HHS) (aHR:2.47 [95% CI 2.33–2.63]) and further to combined DKA-HHS (aHR:2.60 [95% CI 2.29–2.95]). Subgroup analysis in individuals aged ≥ 40 years revealed a similar trend with slightly reduced incidences and HRs. Patients with HC as their initial type 2 diabetes presentation face a higher CKD risk than do those without HC. Enhanced medical attention and customized interventions are crucial to reduce this risk.

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Introduction.

Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) represent life-threatening hyperglycemic crises (HC) in patients with diabetes 1 . Although commonly seen in patients with preexisting diabetes, up to 20% of cases occur in those newly diagnosed 2 , 3 , 4 . Individuals with HC episodes face higher risks of subsequent morbidity and mortality compared with those without such episodes 5 , 6 , 7 . However, limited research explores the risk of chronic complications in patients experiencing HC during diabetes diagnosis, underscoring the need for further investigation.

Previous studies have reported an increased risk of subsequent stroke 8 , 9 , cardiovascular events 10 , long-term mortality 11 , 12 , and end-stage renal disease 13 in patients with diabetes who have experienced an HC. Nevertheless, these studies overlook the confounding effect of glycemic control on the development of diabetes-related chronic complications. Moreover, type 1 and type 2 diabetes possess distinct pathophysiologies and should not be considered as a single entity; however, only two studies exclusively included patients with type 2 diabetes 8 , 9 , and none were conducted in patients with newly diagnosed diabetes. In contrast, an Italian multicenter cohort study demonstrated that patients with DKA upon type 1 diabetes onset were not at an increased risk of diabetic retinopathy or albuminuria 14 . The reasons behind these conflicting findings and the impact of HC that occurs in patients newly diagnosed with type 2 diabetes remain to be elucidated.

Therefore, in this study, we aimed to examine the risk of developing chronic kidney disease (CKD), one of the major chronic complications of diabetes, in patients experiencing HC upon type 2 diabetes diagnosis. We hypothesized that HC occurring upon type 2 diabetes diagnosis is associated with a higher risk of developing CKD. Our findings could hold significance if this unique initial presentation of type 2 diabetes can be utilized to identify patients at increased risk of developing CKD; moreover, it could facilitate the implementation of preventive interventions to reduce CKD risk in this population.

Data sources

In this study, we utilized Taiwan’s insurance claims data to identify adults newly diagnosed with type 2 diabetes between 2006 and 2015. We used the Taiwan National Health Insurance Research Database (NHIRD), a comprehensive repository established in 1995 that covers over 99% of the nation’s residents 15 , 16 . The NHIRD comprises encrypted records encompassing sociodemographic information, household income, residency, outpatient/inpatient care, and prescribed medications. Diseases in the NHIRD are coded using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) before 2016 and Tenth Revision (ICD-10-CM). Previous investigations have validated the NHIRD’s accuracy and reliability for population-based studies 17 , 18 .

Design setting and study cohorts

From the NHIRD, we used the ICD-9-CM or ICD-10-CM and Anatomical Therapeutic Chemical Codes (Tables S1 and Table S2 ) to identify newly diagnosed cases with type 2 diabetes (ICD-9-CM codes: 250. X0 or 250. × 2) during the study period (Fig.  1 ). We excluded individuals who were diagnosed with diabetes or using glucose-lowering drugs before the study period, younger than 20 years of age, had a history of kidney disease including benign or malignant neoplasms of the kidney, chronic kidney disease of any cause, glomerulonephritis, nephrotic syndrome, urolithiasis, and congenital renal anomalies, or were deceased at baseline. Individuals with concurrent HC at the time of their type 2 diabetes diagnosis (first-time type 2 diabetes diagnosis appeared with at least one of the following ICD-9-CM codes: 250.10, 250.12, 250.20, or 250.22) were categorized into the HC cohort. The clinical diagnostic criteria for HC were based on previous guidelines 19 , 20 , and our data were based on diagnostic codes from all medical facilities regardless of inpatient/outpatient care or emergency department visits. Regarding individuals without HC, we selected a control (non-HC) cohort with the same sample size frequency matched by diagnosis year and propensity score. The propensity scores were calculated using multivariable logistic regression for each person at baseline, including sex, age, type of residence, enrollment category, monthly income, comorbidities, and use of angiotensin-converting enzyme inhibitors ( ACEis) or angiotensin II receptor blockers (ARBs) . Comorbidities were diseases with at least two outpatient claims or one inpatient claim within 1 year of the index date and included hypertension, heart failure, coronary artery disease, ischemic stroke, transient ischemic attack, peripheral arterial disease, hyperlipidemia, obesity, and malignancy. Variables with a between-group standardized mean difference of < 0.1 were considered well-balanced 21 . Sodium-glucose cotransporter-2 inhibitors were not included due to their unavailability in Taiwan during the enrollment period.

Flow chart showing the establishment of the hyperglycemic crisis cohort and propensity score matched non-hyperglycemic crisis cohort from the National Health Insurance Research Database, Taiwan, 2006–2018. OAD, oral anti-diabetic agent.

The two cohorts were followed up until the end of 2018. Our outcome of interest was the combined incidence of CKD (ICD-9-CM codes: 585–586; ICD-10-CM code: N184–N186, N189–N19) or diabetic kidney disease (DKD) (ICD-9-CM codes: 250.40 or 250.42; ICD-10-CM: E112), or both. In Taiwan, it is generally accepted that CKD is characterized by a decreased glomerular filtration rate of less than 60 mL/min per 1.73 m 2 and/or markers of kidney damage that persist for longer than 3 months. DKD is a clinical diagnosis that refers to those cases with CKD presumed to be caused by diabetes. Clinicians are free to use whichever code is appropriate based on their judgment. Hence, the data of patients with diabetes and CKD may be coded using CKD, DKD, or both. As DKD is within the spectrum of CKD and our aim was to explore the risk of CKD, we used both codes to maximize the probability of capturing our main outcome of interest.

Institutional review board statement

This study was approved by the Institutional Review Board of Mackay Memorial Hospital (approval number: 22MMHIS382e). Our study was performed in accordance with the Declaration of Helsinki and all our methods were carried out under relevant guidelines and regulations. As all personal identifications in the database were encrypted and unidentifiable, the requirement for informed consent from the insured individuals was waived.

Statistical analysis

Baseline characteristics and comorbidities were compared between the HC and non-HC cohorts using Pearson’s χ 2 test for categorical variables and Student’s t -test for continuous variables. The HC cohort comprised three sub-cohorts: patients with DKA (ICD-9-CM codes: 250.10 or 250.12), HHS (ICD-9-CM codes: 250.20 or 250.22), and combined DKA and HHS (DKA-HHS). The cumulative incidence rate of combined CKD and DKD between the HC and non-HC cohorts, as well as between the HC sub-cohorts, was estimated and plotted using the Kaplan–Meier method. Inter-group differences were examined using the log-rank test. Cox proportional hazards regression analysis was used to calculate the crude hazard ratio comparing the HC and non-HC cohorts; moreover, the adjusted hazard ratio (aHR), along with its corresponding 95% confidence interval (CI), was used for the combined occurrence of CKD and DKD. The aHR was estimated after adjusting for age, sex, socioeconomic factors, and significant comorbidities. As patients who died before the event occurred will never be coded with CKD and/or DKD, the competing risk of death was managed using the Fine-Grey analysis model to estimate the sub-distribution hazard ratio (sHR) 22 . To address potential misclassification and pollution bias from claims data, where type 1 diabetes might have been incorrectly recorded as type 2 diabetes, we performed a subgroup analysis to estimate the combined incidence rates of CKD and DKD for individuals aged 40 years and older. We selected this cutoff because the incidence of type 1 diabetes drops significantly after age 40 years and remains relatively low in this age group. This approach helps to minimize the risk of pollution bias in our results 23 . To validate that the incident events were not the result of undiagnosed preexisting CKD or DKD, a supplementary sensitivity analysis was performed by excluding outcomes that occurred within 6 months after the diagnosis of type 2 diabetes. Finally, we conducted a nested case–control analysis to explore the risk factors for CKD or DKD, including DKA, HHS, acute kidney injury, nonsteroidal anti-inflammatory drug use, and ACEi or ARB use. Medication use was stratified based on the prescription length into three categories: no exposure (0 days), 90 days or less, and more than 90 days. Statistical analyses were performed using the Statistical Package for SAS V. 9.4 (SAS Institute, Cary, North Carolina, USA), and a two-sided P -value of less than 0.05 was considered statistically significant.

Ethics-approval and consent to participate

This study was approved by the Institutional Review Board of Mackay Memorial Hospital (approval number: 22MMHIS382e) and informed consent was waived.

Presentation at a meeting

The current study was presented as an e-poster at the IDF 2022 Congress in Lisbon, Portugal, on December 5–8.

Cohort characteristics

There were 13,242 participants in each cohort (Fig.  1 ), and their baseline characteristics are shown in Table 1 . The mean age of the study participants was approximately 54 years (men: 62%). Compared with the non-HC cohort, the HC cohort had a lower income and higher prevalence of malignancy (6.24% vs. 2.99%, respectively); however, they had a lower prevalence of hypertension (32.7% vs. 37.5%, respectively) and hyperlipidemia (13.2% vs. 20.7%, respectively). The two cohorts did not differ in the proportion of patients who received either ACEis or ARBs.

Combined incidence of CKD and DKD

Table 2 depicts the combined incidence of CKD and DKD in the HC cohort, its sub-cohorts, and in the non-HC cohort. The HC cohort comprised mainly patients with DKA (55.1%) and HHS (39.2%), with a few cases of combined DKA-HHS (5.7%). There were 4106 (31%) and 2735 (20.7%) events observed in the HC and non-HC cohorts during median follow-ups of 4.97 years and 7.15 years, respectively. This corresponded to incidence rates of 56.47 and 28.49 per 1000 person-years, respectively. The cumulative incidence of CKD and DKD was significantly greater in the HC cohort than in the non-HC cohort (Fig.  2 A). Within the HC cohort, the cumulative incidence was higher in patients with HHS and combined DKA-HHS than in those with DKA (Fig.  2 B). The aHR among the HC sub-cohorts increased from 1.69 (95% CI 1.59–1.79) for DKA to 2.47 (95% CI 2.33–2.63) for HHS and 2.60 (95% CI 2.29–2.95) for combined DKA-HHS. In the sub-distribution hazard models, the sHRs were attenuated but remained significantly higher in the main HC cohort and its sub-cohorts.

Group comparisons of the Kaplan–Meier estimated cumulative incidence of combined chronic kidney disease and diabetic kidney disease between hyperglycemic crisis (HC) and non-hyperglycemic crisis (non-HC) cohorts ( A ), and among hyperglycemic hyperosmolar state (HHS), diabetic ketoacidosis (DKA), combined DKA-HHS sub-cohorts and non-HC cohorts ( B ), from the National Health Insurance Research Database, Taiwan, 2006–2018.

Subgroup analysis in individuals aged 40 years and older

There were 10,266 (77.5%) and 10,419 (78.7%) individuals aged 40 years and older in the HC and non-HC cohorts, respectively (Table 3 ). This subgroup comprised 5104 (49.7%) individuals with DKA and 4591 (44.7%) with HHS in the HC cohort. A similar increase in the HR between the HC and non-HC cohorts, compatible with the result in our primary analysis, was observed in this age group. The aHR among the HC sub-cohorts also showed a stepwise escalation from 1.62 (95% CI 1.51–1.72) for DKA to 2.33 (95% CI 2.19–2.49) for HHS and 2.59 (95% CI 2.25–2.98) for combined DKA-HHS.

Sensitivity analysis

The sensitivity analysis demonstrated that the patterns of CKD or DKD development 6 months after the diagnosis of type 2 diabetes were consistent with the findings of the primary analysis (Table S3 ).

Nested case–control analyses

The nested case–control analysis showed that the risk of developing CKD or DKD was significantly higher for patients with a history of hyperlipidemia (adjusted odds ratio [aOR] 1.22; 95% CI 1.15–1.30), acute kidney injury (aOR 1.33; 95% CI 1.18–1.50), DKA (aOR 1.56; 95% CI 1.47–1.66), and HHS (aOR 1.75; 95% CI 1.64–1.86). Compared with patients who did not receive ACEis or ARBs, those who had received treatment with ACEis or ARBs also had a higher risk, with an aOR of 1.93 (95% CI 1.75–2.13) for those treated for 90 days or less and an aOR of 1.69 (95% CI 1.57–1.82) for those who were treated for more than 90 days (Table S4 ).

This population-based cohort study revealed a higher risk of incident CKD and/or DKD in patients with HC as their initial presentation of type 2 diabetes than in patients who present type 2 diabetes without HC. This association remained consistent across all HC sub-cohorts and stayed significant in the subgroup analysis for those aged 40 years and older. The risk was higher in patients with HHS and in those with both DKA and HHS than in those with DKA. This association remained robust after excluding cases that appeared within 6 months of diabetes diagnosis. Our nested case–control analysis corroborates that, compared with patients with type 2 diabetes who did not develop CKD or DKD, those who did were more likely to have experienced HC upon diabetes diagnosis.

The surprisingly high proportion of patients having DKA instead of HHS on the initial presentation of their type 2 diabetes in our cohort may raise concerns of pollution bias by the presence of patients with type 1 diabetes. Although there is currently no data reporting the proportion of DKA versus HHS in patients with HC as the initial presentation of type 2 diabetes, we believe that our findings are valid because previous studies have also reported a high percentage of newly diagnosed type 2 diabetes among patients with DKA. In an early study of 141 episodes of DKA in a tertiary referral center in Taiwan, 32 (22.7%) episodes were caused by newly diagnosed diabetes 24 . Twenty-five of the newly diagnosed patients were followed for at least 12 months, and 11 (44%) of them were not using insulin and exhibited metabolic features of type 2 diabetes. A recent study that retrospectively reviewed the medical records of consecutive patients with index DKA in four general hospitals in Qatar showed that 442 (48%) of them had type 2 diabetes 25 . Of the 324 patients with DKA and newly diagnosed diabetes, 176 (54.3%) had type 2 diabetes, and 93 (52.8%) were Asian. We speculate that the excessive DKA cases observed in our study and previous studies may be attributed to ‘ketosis-prone diabetes (KPD)’ 26 . This syndrome is characterized by the acute onset of severe hyperglycemia with ketoacidosis, necessitating hospital admission and treatment. However, it often undergoes spontaneous remission, with patients maintaining long-term insulin independence several weeks after discharge 27 . Initially identified in individuals of African descent and African Americans 28 , KPD is now recognized as a significant clinical entity in Asian populations 27 . Patients with KPD are typically young or middle-aged and predominantly male 29 , consistent with the clinical characteristics of our study population. Another reason we believe that we secured the cases of type 2 diabetes in our study is due to the unique characteristics of the NHIRD. In Taiwan, type 1 diabetes is classified as a catastrophic illness by the National Health Insurance Administration. When a physician diagnoses a patient with such a condition, the patient can apply for a catastrophic illness certificate by submitting the necessary documentation. Upon issuance, this certification is recorded on the patient’s National Health Insurance Card. During the validity period of this certificate, patients are exempt from co-payment of outpatient or inpatient care related to the certified illness 30 . However, this exemption is contingent upon the physician using the correct ICD codes, as is the case with type 1 diabetes. An incorrect ICD coding that misclassifies type 1 diabetes as type 2 diabetes would prevent patients with type 1 diabetes from receiving exemptions for medical expenses, a scenario which is unlikely to occur in real-world practice or in the NHIRD. Moreover, the result of our subgroup analysis for those aged 40 years and older, which comprised nearly 78% of all patients, did not differ from our main findings. As the incidence of type 2 diabetes increases with age in Taiwan, and the incidence of type 1 diabetes over 40 years of age is remarkably low (0.02 per 100,000 population) 23 , the possibility that our findings are biased due to the presence of patients with type 1 diabetes is negligibly low.

Our findings align with those of previous Taiwan NHIRD studies demonstrating the detrimental effects of HC in patients with diabetes 8 , 9 , 10 , 11 , 12 , 13 . The present research adds value to the previous literature in several aspects. First, unlike previous studies that examined diabetes as a single entity 10 , 11 , 12 , 13 , we focused exclusively on type 2 diabetes and examined the individual effects of different types of HC. Given the distinct pathophysiologies underlying DKA and HHS, as well as those underlying type 1 and type 2 diabetes, our study design may ensure a more robust association between HC and CKD. The higher risk of CKD and/or DKD observed in patients with HHS or those with combined DKA-HHS than in patients with isolated DKA also aligns with previous studies reporting worse in-hospital outcomes in patients with combined DKA-HHS than in those with isolated DKA or HHS 31 . Second, HC typically signifies uncontrolled diabetes 32 , which is a well-recognized risk factor for diabetic complications 33 . Studies not adjusting for patients’ glycemic control may confound the impact of HC on long-term outcomes. We minimized such confounding by focusing on patients newly diagnosed with diabetes, where subsequent glycemic control acts as a mediator or effect modifier that requires no adjustment. Third, this pioneering study investigates the impact of HC on patients newly diagnosed with type 2 diabetes without prior kidney disease, offering potential insights for future clinical practice. Given their increased risk of CKD, patients experiencing HC upon type 2 diabetes diagnosis should receive proactive early preventive measures to mitigate such risk.

Several mechanisms may explain our findings. A longitudinal study on type 2 diabetes in Taiwan highlighted that individuals with lower income levels were more likely to have hospitalization-diagnosed diabetes, although it did not report how many of these patients were diagnosed via HC 34 . Patients with type 2 diabetes who are not diagnosed until hospitalization may be less likely to receive early detection screenings or may lack sufficient awareness of diabetes-related symptoms to seek appropriate healthcare 34 . Although the two study groups in our study did not differ in most baseline characteristics after propensity-score matching, individuals in the HC group exhibited significantly lower income levels than those in the non-HC group. Such difference may suggest that our HC group, compared with the non-HC group, included more individuals facing healthcare inequality, potentially resulting in worse renal outcomes. Furthermore, common risk factors for CKD, such as hypertension and hyperlipidemia, often remain undiagnosed among underprivileged individuals 35 . The paradoxically higher risk of CKD despite a lower prevalence of hypertension and hyperlipidemia in the HC group than in the non-HC group may be a result of more undiagnosed rather than healthier cases in the former group. As our propensity score considered only established comorbidities, the true risk difference of CKD at baseline between the two groups may be unbalanced. This could explain the remaining two-fold higher risk of CKD in the HC group, even after adjusting for income level, comorbidities, and other covariates.

From a biological perspective, our finding may be a consequence of initial priming by hyperglycemia, as the onset of diabetes followed by subsequent insults from acute kidney injury (AKI) during HC ultimately leads to persistent nephron damage. Hyperglycemia-induced epigenetic change can lead to progressive and irreversible renal injury, a phenomenon known as the “metabolic memory of DKD” 36 . Following exposure to hyperglycemia, vascular endothelial cells continue to increase oxidative stress and elicit inflammation even after normalization of blood glucose levels 37 . Owing to the slow progression of type 2 diabetes, the exact duration between disease onset and diagnosis is difficult to ascertain. Previous studies have suggested that the interval between the onset and diagnosis of type 2 diabetes is at least 5 years 38 , 39 . Moreover, low income is significantly associated with delayed diagnosis and inadequate diabetes care and management 34 . We speculate that patients experiencing HC upon diabetes diagnosis had a longer duration from diabetes onset to diagnosis compared with those who had diabetes diagnosed without HC. Such a latent period aggravates metabolic memory and leads to an increased risk of CKD. Moreover, AKI is a known risk factor for CKD 40 , 41 , 42 and is common in patients with DKA due to volume depletion 7 , 43 . Despite this, there is a paucity of data reporting the incidence of AKI during HHS. A higher rate of AKI in patients with HHS is expected as patients with HHS are more likely to be dehydrated than patients with DKA. The occurrence of AKI during HC may exacerbate renal damage and increase the risk of CKD. A recent study revealed a higher incidence of AKI in patients with HHS and combined DKA-HHS than in those with DKA 44 , which may also explain the greater risk of CKD in patients with HHS and combined DKA-HHS than in those with DKA in our study. Nevertheless, we cannot exclude the possibility that our findings result from surveillance bias between the two cohorts. As patients experiencing HC upon diabetes diagnosis have more severe disease compared with those without HC at diagnosis, clinicians should provide more vigilant follow-ups for earlier detection of CKD.

This study had some limitations. First, relying solely on claims data may have led to the misclassification of diseases. However, the accuracy and validity of the NHIRD claims data have been demonstrated previously 15 , 17 , 18 , minimizing the impact of misclassification on our results. Second, we could not adjust for covariates unavailable in the NHIRD, including laboratory tests, blood pressure, waist circumference, body mass index, and lifestyle. The potential impact of this missing data remains unassessed. Furthermore, the inherent limitations of the NHIRD also restricted us from determining the severity of DKA and the stage of CKD, which may also have affected our results. Third, in large-sample studies, even minor differences can achieve statistical significance, warranting cautious interpretation. Because we established our study cohorts using a propensity score-matched design and conducted the analysis using stratification, we believe that the observed risk differences between the two cohorts were not a result of overpowering. Finally, the generalizability of our findings may be limited to populations with similar characteristics.

Conclusions

Patients who experience HC upon type 2 diabetes diagnosis have a higher risk of developing CKD compared with those without HC at diagnosis. As type 2 diabetes and end-stage renal disease are highly prevalent in Taiwan, proactive preventive measures are imperative to mitigate risks in this vulnerable population. These interventions should include early introduction of ACEis or ARBs and sodium-glucose cotransporter-2 inhibitors, stringent control of diabetes and the reduction of other risk factors, and educational programs for continuous diabetes self-care management. Furthermore, healthcare authorities should reinforce government-subsidized diabetes screening programs, especially for the underprivileged, to facilitate early recognition of undiagnosed diabetes and prevent HC incidents.

Data availability

No original data were generated or collected as part of this study. The NHIRD used in this study is available from the Taiwan National Health Insurance Administration, Ministry of Health and Welfare.

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Acknowledgements

We are grateful to the Health Data Science Center of China Medical University Hospital for providing administrative, technical, and funding support.

This work was supported in part by the Taiwan Ministry of Health and Welfare Clinical Trial Center (Grant Number: MOHW110-TDU-B-212-124004), the Ministry of Science and Technology (grant number: MOST 110-2321-B-039-003), and China Medical University Hospital (Grant Numbers: DMR-111-228 and CMU110-MF-63). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Conception and design: CT, FC. Acquisition, analysis, and interpretation of data: all authors. Drafting of the manuscript: CT. Critical revision of the manuscript for important intellectual content: all authors. Statistical analysis: CH. Obtained funding: FC, PC. All authors had full access to all the study data and take responsibility for its integrity and the accuracy of data analysis. All authors have read and approved the final version of the manuscript submitted for publication.

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Huang, CT., Muo, CH., Sung, FC. et al. Risk of chronic kidney disease in patients with a hyperglycemic crisis as the initial presentation of type 2 diabetes. Sci Rep 14 , 16746 (2024). https://doi.org/10.1038/s41598-024-67678-3

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Risk of chronic kidney disease in patients with a hyperglycemic crisis as the initial presentation of type 2 diabetes

Affiliations.

• 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Mackay Memorial Hospital, Taipei City, 104217, Taiwan.
• 2 Department of Medicine, Mackay Medical College, New Taipei City, 252005, Taiwan.
• 3 Management Office for Health Data, China Medical University Hospital, Taichung City, 404328, Taiwan.
• 4 Management Office for Health Data, China Medical University Hospital, Taichung City, 404328, Taiwan. [email protected].
• 5 Department of Health Services Administration, China Medical University College of Public Health, 100 Jingmao Road Section 1, Beitun Dist., Taichung, 406040, Taiwan. [email protected].
• 6 Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, 413305, Taiwan. [email protected].
• 7 International Master Program for Public Health, China Medical University, Taichung, 406040, Taiwan.
• PMID: 39033190
• DOI: 10.1038/s41598-024-67678-3

Limited data exist on long-term renal outcomes in patients with hyperglycemic crisis (HC) as initial type 2 diabetes presentation. We evaluated the risk of chronic kidney disease (CKD) development in those with concurrent HC at diagnosis. Utilizing Taiwan's insurance claims from adults newly diagnosed with type 2 diabetes during 2006-2015, we created HC and matched non-HC cohorts. We assessed incident CKD/diabetic kidney disease (DKD) by 2018's end, calculating the hazard ratio (HR) with the Cox model. Each cohort comprised 13,242 patients. The combined CKD and DKD incidence was two-fold higher in the HC cohort than in the non-HC cohort (56.47 versus 28.49 per 1000 person-years) with an adjusted HR (aHR) of 2.00 (95% confidence interval [CI] 1.91-2.10]). Risk increased from diabetic ketoacidosis (DKA) (aHR:1.69 [95% CI 1.59-1.79]) to hyperglycemic hyperosmolar state (HHS) (aHR:2.47 [95% CI 2.33-2.63]) and further to combined DKA-HHS (aHR:2.60 [95% CI 2.29-2.95]). Subgroup analysis in individuals aged ≥ 40 years revealed a similar trend with slightly reduced incidences and HRs. Patients with HC as their initial type 2 diabetes presentation face a higher CKD risk than do those without HC. Enhanced medical attention and customized interventions are crucial to reduce this risk.

Keywords: Chronic kidney disease; Diabetic ketoacidosis; Diabetic kidney disease; Hyperglycemic crisis; Hyperglycemic hyperosmolar state.

© 2024. The Author(s).

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Grants and funding

• MOHW110-TDU-B-212-124004/Ministry of Health and Welfare
• MOST 110-2321-B-039-003/Ministry of Science and Technology, Taiwan
• DMR-111-228/China Medical University Hospital
• CMU110-MF-63/China Medical University Hospital

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