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PubMed Central ® (PMC) is a free full-text archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine (NIH/NLM)
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Dec. 15, 2023
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Second Phase of the NIH Preprint Pilot Launched
The second phase launched in January 2023 and expands the scope of the Pilot to include preprints resulting from all NIH-funded research.
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Medical research articles from across Nature Portfolio
Medical research involves research in a wide range of fields, such as biology, chemistry, pharmacology and toxicology with the goal of developing new medicines or medical procedures or improving the application of those already available. It can be viewed as encompassing preclinical research (for example, in cellular systems and animal models) and clinical research (for example, clinical trials).
Synthesis of large polysaccharides facilitates identification of an active glycan domain
A preactivation-based one-pot glycosylation strategy was used to synthesize RN1 — a polysaccharide comprising 140 monosaccharide units isolated from Panax notoginseng , as well as a glycan fragment library. Evaluation of the biological activity of the glycans in vitro revealed that a decasaccharide fragment shows anti-pancreatic cancer activity.
Screening for drivers of SARS-CoV-2 uptake
Genetic and cellular drivers of the cellular uptake of SARS-CoV-2 can be screened at high throughput via droplet microfluidics and size-exclusion methods for the analysis of the formation of fusions between cells expressing the virus’s spike protein and cells expressing the protein’s receptor.
- Alexis Autour
- Christoph A. Merten
Tackling inappropriate antibiotic use in low-and middle-income countries
New data show that electronic clinical decision support systems integrated with point-of-care tests can lead to meaningful reductions in antibiotic use in children in low- and middle-income countries, without compromising health outcomes — but investment in human resources is crucial to their success.
- Sena Sayood
- Julia Bielicki
- Sumanth Gandra
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Addressing gaps in healthcare provider knowledge regarding germline testing for prostate cancer through development and testing of a virtual genetics board.
- Heather H. Cheng
- Veda N. Giri
Endoscopic healing is associated with a reduced risk of biologic treatment failure in patients with ulcerative colitis
- Akira Komatsu
- Takahiko Toyonaga
- Masayuki Saruta
Effects of photoperiod and food on glucose intolerance and subsequent ocular pathology in the fat sand rat
- Carmel Bilu
- Neta Butensky
- Vicktoria Vishnevskia-Dai
The application and influence of “Small Private Online Course” based on flipped classroom teaching model in the course of fundamental operations in surgery in China
- Xiaoyi Zhou
Tailored radiation dose according to margin width for patients with ductal carcinoma in situ after breast-conserving surgery
- Hyunjung Kim
- Tae Gyu Kim
- Haeyoung Kim
18 F-FDG PET/CT features of Meigs syndrome induced by ovarian sex cord stromal tumors: a retrospective clinical study
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How to interpret the euro-ski study and its treatment-free remission outcome. reply to r.p. gale and j. chen.
- Markus Pfirrmann
- Susanne Saussele
- Johan Richter
A new class of antibiotics is cause for cautious celebration — but the economics must be fixed
The threat of antimicrobial resistance means that new antibiotics need to be used sparingly. Governments must support their development with a long-term funding plan.
Long COVID is a double curse in low-income nations — here’s why
Not only is the prevalence of the condition poorly understood, but it’s also often ignored by physicians and the wider public.
- Heidi Ledford
A decentralized delivery program for rheumatic heart disease treatment and prevention in Uganda
- Doreen Nakagaayi
- Jafesi Pulle
- David Watkins
Coming home to roost
Rebecca Fitzgerald completed her medical degree at the University of Cambridge, followed by doctoral research at Stanford University, and then postdoctoral research alongside specialist training in gastroenterology at Barts and the London Hospitals. She started her own independent group the MRC Cancer Unit in 2001 with an honorary gastroenterology consultant position at Addenbrooke’s Hospital. In 2014, she was elected to chair in cancer prevention, and in 2022 inaugural director of the department of oncology at the Early Cancer Institute, University of Cambridge.
- Rebecca Fitzgerald
From lab to life: how wearable devices can improve health equity
Wearable devices can provide personalised medicine at the point of need, potentially increasing access to health services and therefore improving health equity. Here the authors discuss their experiences developing wearable devices for vulnerable patient populations, including neonates and pregnant individuals.
- Jessica R. Walter
- John A. Rogers
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