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PubMed Central ® (PMC) is a free full-text archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine (NIH/NLM)

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Medical research articles from across Nature Portfolio

Medical research involves research in a wide range of fields, such as biology, chemistry, pharmacology and toxicology with the goal of developing new medicines or medical procedures or improving the application of those already available. It can be viewed as encompassing preclinical research (for example, in cellular systems and animal models) and clinical research (for example, clinical trials).

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Synthesis of large polysaccharides facilitates identification of an active glycan domain

A preactivation-based one-pot glycosylation strategy was used to synthesize RN1 — a polysaccharide comprising 140 monosaccharide units isolated from Panax notoginseng , as well as a glycan fragment library. Evaluation of the biological activity of the glycans in vitro revealed that a decasaccharide fragment shows anti-pancreatic cancer activity.

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Screening for drivers of SARS-CoV-2 uptake

Genetic and cellular drivers of the cellular uptake of SARS-CoV-2 can be screened at high throughput via droplet microfluidics and size-exclusion methods for the analysis of the formation of fusions between cells expressing the virus’s spike protein and cells expressing the protein’s receptor.

  • Alexis Autour
  • Christoph A. Merten

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Tackling inappropriate antibiotic use in low-and middle-income countries

New data show that electronic clinical decision support systems integrated with point-of-care tests can lead to meaningful reductions in antibiotic use in children in low- and middle-income countries, without compromising health outcomes — but investment in human resources is crucial to their success.

  • Sena Sayood
  • Julia Bielicki
  • Sumanth Gandra

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Latest Research and Reviews

Addressing gaps in healthcare provider knowledge regarding germline testing for prostate cancer through development and testing of a virtual genetics board.

  • Heather H. Cheng
  • Veda N. Giri

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Endoscopic healing is associated with a reduced risk of biologic treatment failure in patients with ulcerative colitis

  • Akira Komatsu
  • Takahiko Toyonaga
  • Masayuki Saruta

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Effects of photoperiod and food on glucose intolerance and subsequent ocular pathology in the fat sand rat

  • Carmel Bilu
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  • Vicktoria Vishnevskia-Dai

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The application and influence of “Small Private Online Course” based on flipped classroom teaching model in the course of fundamental operations in surgery in China

  • Xiaoyi Zhou

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Tailored radiation dose according to margin width for patients with ductal carcinoma in situ after breast-conserving surgery

  • Hyunjung Kim
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18 F-FDG PET/CT features of Meigs syndrome induced by ovarian sex cord stromal tumors: a retrospective clinical study

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How to interpret the euro-ski study and its treatment-free remission outcome. reply to r.p. gale and j. chen.

  • Markus Pfirrmann
  • Susanne Saussele
  • Johan Richter

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A new class of antibiotics is cause for cautious celebration — but the economics must be fixed

The threat of antimicrobial resistance means that new antibiotics need to be used sparingly. Governments must support their development with a long-term funding plan.

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Long COVID is a double curse in low-income nations — here’s why

Not only is the prevalence of the condition poorly understood, but it’s also often ignored by physicians and the wider public.

  • Heidi Ledford

A decentralized delivery program for rheumatic heart disease treatment and prevention in Uganda

  • Doreen Nakagaayi
  • Jafesi Pulle
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research paper related to medicine

Coming home to roost

Rebecca Fitzgerald completed her medical degree at the University of Cambridge, followed by doctoral research at Stanford University, and then postdoctoral research alongside specialist training in gastroenterology at Barts and the London Hospitals. She started her own independent group the MRC Cancer Unit in 2001 with an honorary gastroenterology consultant position at Addenbrooke’s Hospital. In 2014, she was elected to chair in cancer prevention, and in 2022 inaugural director of the department of oncology at the Early Cancer Institute, University of Cambridge.

  • Rebecca Fitzgerald

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From lab to life: how wearable devices can improve health equity

Wearable devices can provide personalised medicine at the point of need, potentially increasing access to health services and therefore improving health equity. Here the authors discuss their experiences developing wearable devices for vulnerable patient populations, including neonates and pregnant individuals.

  • Jessica R. Walter
  • John A. Rogers

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Research articles

Christmas 2023: common healthcare related instruments subjected to magnetic attraction study, using autoregressive integrated moving average models for time series analysis of observational data, demand for morning after pill following new year holiday, christmas 2023: christmas recipes from the great british bake off, effect of a doctor working during the festive period on population health: experiment using doctor who episodes, christmas 2023: analysis of barbie medical and science career dolls, christmas 2023: effect of chair placement on physicians’ behavior and patients’ satisfaction, management of chronic pain secondary to temporomandibular disorders, christmas 2023: projecting complete redaction of clinical trial protocols, christmas 2023: a drug target for erectile dysfunction to help improve fertility, sexual activity, and wellbeing, christmas 2023: efficacy of cola ingestion for oesophageal food bolus impaction, conservative management versus laparoscopic cholecystectomy in adults with gallstone disease, social media use and health risk behaviours in young people, untreated cervical intraepithelial neoplasia grade 2 and cervical cancer, air pollution deaths attributable to fossil fuels, implementation of a high sensitivity cardiac troponin i assay and risk of myocardial infarction or death at five years, covid-19 vaccine effectiveness against post-covid-19 condition, association between patient-surgeon gender concordance and mortality after surgery, intravascular imaging guided versus coronary angiography guided percutaneous coronary intervention, treatment of lower urinary tract symptoms in men in primary care using a conservative intervention, autism intervention meta-analysis of early childhood studies, effectiveness of the live zoster vaccine during the 10 years following vaccination, effects of a multimodal intervention in primary care to reduce second line antibiotic prescriptions for urinary tract infections in women, pyrotinib versus placebo in combination with trastuzumab and docetaxel in patients with her2 positive metastatic breast cancer, association of dcis size and margin status with risk of developing breast cancer post-treatment, racial differences in low value care among older patients in the us, pharmaceutical industry payments and delivery of low value cancer drugs, rosuvastatin versus atorvastatin in adults with coronary artery disease, clinical effectiveness of septoplasty versus medical management for nasal airways obstruction, ultrasound guided lavage with corticosteroid injection versus sham lavage with and without corticosteroid injection for calcific tendinopathy of shoulder, early versus delayed antihypertensive treatment in patients with acute ischaemic stroke, mortality risks associated with floods in 761 communities worldwide, interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities, association between changes in carbohydrate intake and long term weight changes, future-case control crossover analysis for adjusting bias in case crossover studies, association between recently raised anticholinergic burden and risk of acute cardiovascular events, suboptimal gestational weight gain and neonatal outcomes in low and middle income countries: individual participant data meta-analysis, efficacy and safety of an inactivated virus-particle vaccine for sars-cov-2, effect of invitation letter in language of origin on screening attendance: randomised controlled trial in breastscreen norway, visits by nurse practitioners and physician assistants in the usa, non-erosive gastro-oesophageal reflux disease and oesophageal adenocarcinoma, venous thromboembolism with use of hormonal contraception and nsaids, food additive emulsifiers and risk of cardiovascular disease, balancing risks and benefits of cannabis use, promoting activity, independence, and stability in early dementia and mild cognitive impairment, effect of home cook interventions for salt reduction in china, cancer mortality after low dose exposure to ionising radiation, effect of a smartphone intervention among university students with unhealthy alcohol use, long term risk of death and readmission after hospital admission with covid-19 among older adults, mortality rates among patients successfully treated for hepatitis c, association between antenatal corticosteroids and risk of serious infection in children, the proportions of term or late preterm births after exposure to early antenatal corticosteroids, and outcomes, safety of ba.4-5 or ba.1 bivalent mrna booster vaccines, comparative effectiveness of booster vaccines among adults aged ≥50 years, third dose vaccine schedules against severe covid-19 during omicron predominance in nordic countries, private equity ownership and impacts on health outcomes, costs, and quality, healthcare disruption due to covid-19 and avoidable hospital admission, educational inequalities in mortality and their mediators among generations across four decades, prevalence and predictors of data and code sharing in the medical and health sciences, medicare eligibility and in-hospital treatment patterns and health outcomes for patients with trauma, therapeutic value of first versus supplemental indications of drugs in us and europe, hospital admissions linked to sars-cov-2 infection in children and adolescents, vitamin d supplementation and major cardiovascular events, menopausal hormone therapy and dementia, associations between modest reductions in kidney function and adverse outcomes in young adults, association between surgeon volume and patient outcomes after elective shoulder replacement surgery, risk prediction of covid-19 related death or hospital admission in adults testing positive for sars-cov-2, effectiveness of grace risk score in patients admitted to hospital with non-st elevation acute coronary syndrome, peer reviewers’ response to invitations by gender and geographical region, breast cancer mortality in women with early invasive breast cancer, mmr vaccine at age 6 months and hospitalisation for infection before age 12 months, recovery up to two years after sars-cov-2 infection, race-free estimated glomerular filtration rate equation in kidney transplant recipients, risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases, optimising prescribing in older adults with multimorbidity and polypharmacy in primary care, sars-cov-2 infection in vaccinated versus unvaccinated us veterans, women and non-white people among lasker award recipients from 1946 to 2022, effectiveness of spironolactone for women with acne vulgaris, association between inequalities in human resources for health and all cause and cause specific mortality, development and internal-external validation of statistical and machine learning models for breast cancer prognostication, fda approval, clinical trial evidence, efficacy, epidemiology, and price for non-orphan and ultra-rare, rare, and common orphan cancer drug indications, association of early life physical and sexual abuse with premature mortality among female nurses, association between covid vaccination and healthcare contacts for menstrual disturbance and bleeding, fracture risk reduction and safety by osteoporosis treatment in women, intervention to improve management of antibiotics for children presenting to primary care with acute cough and rti, molnupiravir and risk of post-acute sequelae of covid-19, beverage consumption and mortality among adults with type 2 diabetes, surgical versus non-surgical treatment for sciatica, denosumab and incidence of type 2 diabetes among adults with osteoporosis, nirmatrelvir and risk of hospital admission or death in adults with covid, benefits and harms of drug treatment for type 2 diabetes, ambient air pollution and clinical dementia, dietary sugar consumption and health, communication about anticancer drugs to patients and clinicians, comparison of seven popular dietary programmes and risk of mortality, update to living systematic review on prophylaxis against covid-19, effectiveness and safety of analgesic medicines for adults with low back pain, estimated impact of withdrawing primary care financial incentives on quality of care, maternal opioid treatment after delivery and risk of adverse infant outcomes, comparative effectiveness of bnt162b2 versus mrna-1273 covid-19 vaccine boosting, follow us on, content links.

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    The New England Journal of Medicine: Research & Review Articles on Disease & Clinical Practice Original Article Sparsentan in Focal Segmental Glomerulosclerosis M.N. Rheault and Others

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    PubMed Central ® (PMC) is a free full-text archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine (NIH/NLM) About PMC Discover a digital archive of scholarly articles, spanning centuries of scientific research. User Guide

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    Heart Health The case of the bad placebo Published September 13, 2022 A trial from 2019 showed a medication dramatically reduced triglyceride levels in participants, but subsequent analysis found that the placebo used in the trial may have negatively affected those assigned to take it. Diseases & Conditions

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    Research articles Showing results 1-100 Sorted by: Most recent Christmas 2023: Common Healthcare Related Instruments Subjected To Magnetic Attraction Study December 21, 2023 Using autoregressive integrated moving average models for time series analysis of observational data December 20, 2023

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