A model of miRNA-mediated gene silencing; findings from single-molecule
Gene Silencing
Two-step model for the mechanism of gene silencing induced by
Schematic representation of mechanism of gene silencing by miRNAs and
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Q17 BT 2021
RNA Interference (RNAi): Application in Crop Improvement
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The sound of silence: Transgene silencing in mammalian cell
Transgene silencing represents a bottleneck for many mammalian-cell-based biotechnology applications (Figure 1 B).For instance, in industrial cell lines such as Chinese hamster ovary (CHO) cells, or human embryonic kidney (HEK) 293 cells, the silencing of integrated transgenes reduces the long-term production yield for biopharmaceutical manufacturing. 21, 22 Similarly, silencing of sense-and ...
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Transgene silencing represents a bottleneck for many mammalian-cell-based biotechnology applications (Figure 1 B).For instance, in industrial cell lines such as Chinese hamster ovary (CHO) cells, or human embryonic kidney (HEK) 293 cells, the silencing of integrated transgenes reduces the long-term production yield for biopharmaceutical manufacturing. 21, 22 Similarly, silencing of sense-and ...